TGFB1

TGFB1
Structures disponibles PDB Recherche d'orthologue : PDBe RCSB Identifiants PDB 1KLA, 1KLC, 1KLD, 3KFD, 4KV5
Identifiants
Alias	TGFB1
IDs externes	OMIM: 190180 MGI: 98725 HomoloGene: 540 GeneCards: TGFB1
Position du gène (humain) Chr. Chromosome 19 humain Locus 19q13.2 Début 41,301,587 bp Fin 41,353,922 bp
Position du gène (souris) Chr. Chromosome 7 (souris) Locus 7 A3|7 13.98 cM Début 25,386,427 bp Fin 25,404,502 bp
Expression génique Bgee Humain Souris (orthologue) Fortement exprimé dans granulocyte monocyte stromal cell of endometrium aorte ascendante Descending thoracic aorta artère coronaire droite rate poumon droit endocol sang Fortement exprimé dans molaire tibiofemoral joint stroma of bone marrow granulocyte calvaria ganglion mésentérique rate lower jaw thymus corps du fémur Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire type II transforming growth factor beta receptor binding protein N-terminus binding cytokine activity liaison enzymatique growth factor activity liaison d'antigène type I transforming growth factor beta receptor binding protein homodimerization activity protein serine/threonine kinase activator activity liaison protéique protein heterodimerization activity type III transforming growth factor beta receptor binding transforming growth factor beta receptor binding identical protein binding Composant cellulaire cytoplasme région extracellulaire noyau microvillosité surface cellulaire blood microparticle membrane plasmique secretory granule axone soma Golgi lumen platelet alpha granule lumen matrice extracellulaire milieu extracellulaire Processus biologique positive regulation of histone deacetylation positive regulation of transcription regulatory region DNA binding ureteric bud development tolerance induction to self antigen positive regulation of protein phosphorylation endoderm development response to cholesterol positive regulation of MAP kinase activity regulation of sodium ion transport response to progesterone régulation négative du cycle cellulaire response to organic substance mammary gland development T cell homeostasis negative regulation of ossification negative regulation of hyaluronan biosynthetic process phosphorylation des protéines T cell differentiation positive regulation of vascular permeability animal organ regeneration positive regulation of blood vessel endothelial cell migration negative regulation of epithelial cell proliferation regulation of binding inner ear development myélinisation negative regulation of macrophage cytokine production prolifération cellulaire transforming growth factor beta receptor signaling pathway face morphogenesis negative regulation of cell population proliferation positive regulation of receptor clustering regulation of apoptotic process positive regulation of collagen biosynthetic process cellular response to transforming growth factor beta stimulus pathway-restricted SMAD protein phosphorylation regulation of DNA binding regulation of actin cytoskeleton reorganization negative regulation of fat cell differentiation positive regulation of protein metabolic process cell-cell junction organization negative regulation of myoblast differentiation positive regulation of protein kinase B signaling common-partner SMAD protein phosphorylation positive regulation of branching involved in ureteric bud morphogenesis SMAD protein signal transduction epidermal growth factor receptor signaling pathway macrophage derived foam cell differentiation negative regulation of blood vessel endothelial cell migration positive regulation of protein dephosphorylation extrinsic apoptotic signaling pathway negative regulation of extracellular matrix disassembly mitotic cell cycle checkpoint signaling positive regulation of fibroblast proliferation negative regulation of cell differentiation regulation of branching involved in mammary gland duct morphogenesis positive regulation of exit from mitosis negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of gene expression morphogenesis of a branching structure regulation of SMAD protein signal transduction positive regulation of peptidyl-serine phosphorylation activation d'une cellule negative regulation of neuroblast proliferation régulation positive de la transcription dépendante de l'ADN croissance cellulaire negative regulation of T cell proliferation response to wounding negative regulation of cell growth positive regulation of chemotaxis protein export from nucleus regulation of protein import into nucleus positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein import into nucleus positive regulation of cardiac muscle cell differentiation oligodendrocyte development positive regulation of interleukin-17 production réponse inflammatoire negative regulation of interleukin-17 production lymph node development T cell activation voie de signalisation Notch negative regulation of protein phosphorylation regulation of blood vessel remodeling SMAD protein complex assembly regulation of striated muscle tissue development response to vitamin D chondrocyte differentiation regulatory T cell differentiation regulation of cartilage development branch elongation involved in mammary gland duct branching positive regulation of bone mineralization positive regulation of epithelial cell proliferation gestation cellular response to organic cyclic compound positive regulation of extracellular matrix assembly cellular calcium ion homeostasis cicatrisation negative regulation of transcription by RNA polymerase II response to glucose positive regulation of epithelial to mesenchymal transition cellular response to dexamethasone stimulus negative regulation of production of miRNAs involved in gene silencing by miRNA mitigation of host defenses by virus lens fiber cell differentiation positive regulation of NF-kappaB transcription factor activity extracellular matrix assembly ATP biosynthetic process hematopoietic progenitor cell differentiation regulation of interleukin-23 production positive regulation of protein secretion frontal suture morphogenesis Transition épithélio-mésenchymateuse phosphate-containing compound metabolic process régulation de l'expression des gènes adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of release of sequestered calcium ion into cytosol response to radiation mononuclear cell proliferation negative regulation of transcription, DNA-templated negative regulation of T cell activation positive regulation of odontogenesis lipopolysaccharide-mediated signaling pathway positive regulation of protein localization to nucleus response to estradiol regulation of cell migration response to hypoxia hyaluronan catabolic process negative regulation of phagocytosis response to organic cyclic compound positive regulation of protein-containing complex assembly protein kinase B signaling negative regulation of cell-cell adhesion negative regulation of gene silencing by miRNA positive regulation of regulatory T cell differentiation cellular response to growth factor stimulus positive regulation of pathway-restricted SMAD protein phosphorylation mammary gland branching involved in thelarche response to laminar fluid shear stress vieillissement regulation of regulatory T cell differentiation platelet degranulation negative regulation of DNA replication myeloid dendritic cell differentiation salivary gland morphogenesis receptor catabolic process MAPK cascade positive regulation of histone acetylation regulation of transforming growth factor beta receptor signaling pathway positive regulation of phosphatidylinositol 3-kinase activity negative regulation of protein localization to plasma membrane positive regulation of NAD+ ADP-ribosyltransferase activity negative regulation of immune response regulation of cell population proliferation negative regulation of skeletal muscle tissue development positive regulation of peptidyl-threonine phosphorylation positive regulation of smooth muscle cell differentiation positive regulation of isotype switching to IgA isotypes connective tissue replacement involved in inflammatory response wound healing ossification involved in bone remodeling positive regulation of apoptotic process positive regulation of vascular endothelial growth factor production positive regulation of superoxide anion generation digestive tract development migration cellulaire positive regulation of fibroblast migration positive regulation of cell division germ cell migration positive regulation of transcription by RNA polymerase II negative regulation of mitotic cell cycle positive regulation of SMAD protein signal transduction positive regulation of pri-miRNA transcription by RNA polymerase II positive regulation of gene expression positive regulation of cell population proliferation régénération du foie regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of mononuclear cell migration cellular response to insulin-like growth factor stimulus positive regulation of cell migration response to immobilization stress cellular response to mechanical stimulus cellular response to ionizing radiation vasculogenèse neural tube closure heart valve morphogenesis développement du cœur neural tube development membrane protein intracellular domain proteolysis leukocyte migration ventricular cardiac muscle tissue morphogenesis positive regulation of ERK1 and ERK2 cascade transforming growth factor beta receptor signaling pathway involved in heart development embryonic liver development BMP signaling pathway développement d'une cellule apoptose regulation of pri-miRNA transcription by RNA polymerase II positive regulation of production of miRNAs involved in gene silencing by miRNA regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 7040 21803 Ensembl ENSG00000105329 ENSMUSG00000002603 UniProt P01137 P04202 RefSeq (mRNA) NM_000660 NM_011577 RefSeq (protéine) NP_000651 NP_035707 Localisation (UCSC) Chr 19: 41.3 – 41.35 Mb Chr 7: 25.39 – 25.4 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

TGFB1 est un gène situé sur le chromosome 19 humain.

Maladies liées

• Maladie de Camurati-Engelmann
• Maladie inflammatoire infantile de l'intestin avec atteinte neurologique
• Mucoviscidose

Voir aussi

• Facteur de croissance transformant bêta