Esproquin

Esproquin
Clinical data
Other names	Esproquine
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name 2-(3-Ethylsulfinylpropyl)-3,4-dihydro-1H-isoquinoline;
CAS Number	37517-33-2;
PubChem CID	31951;
UNII	3JYK9XFM9K;
CompTox Dashboard (EPA)	DTXSID40865872 ;
Chemical and physical data
Formula	C14H21NOS
Molar mass	251.39 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(CC)CCCN1CC=2C=CC=CC2CC1;

Esproquin is an α₂-adrenergic receptor agonist derived from tetrahydroisoquinoline.^[1] It has a positive inotropic effect, suggesting potential use in treatment of chronic heart failure.^[2]

References

↑ Gray AP, Shiley RH (July 1973). "Preparation and cardiovascular actions of a group of tetrahydroisoquinoline derivatives". Journal of Medicinal Chemistry. 16 (7): 859–61. doi:10.1021/jm00265a028. PMID 4146907.
↑ Kotelanski B, Grozmann RJ, Cohn JN (1973). "Positive inotropic effect of oral esproquin in normal subjects". Clinical Pharmacology and Therapeutics. 14 (3): 427–33. doi:10.1002/cpt1973143427. PMID 4698571. S2CID 46266823.

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