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Alcohol causes progressive neurological damage. The WCTU's concept of 'Scientific Temperance Instruction' included teaching children how alcohol damaged the brain and nervous system. This was accurate medicine for the 1880s.
A prime example of the damage marijuana does to the prefrontal cortex: the replies.
Just look at the disproportionate anger and total lack of emotional regulation and impulse control from the stoners the moment anyone criticizes weed.
By 1900 the Anti-Saloon League had converted its religious network into a political machine that could mobilize voters in every congressional district. That level of organization was unprecedented and unprecedented effective.
The world's first Total Abstinence Society was founded in Portland, Maine in 1815. The city that produced Carrie Nation's Maine Law in 1851 also produced the world's first total abstinence society. Maine led.