Journal of Integrative Neuroscience

P-ISSN: 0219-6352

E-ISSN: 1757-448X

Journal of Integrative Neuroscience (JIN) is an international peer-reviewed, open access journal. The journal is devoted to publishing cutting-edge research in all areas of neuroscience, and welcomes research contributions on molecular, cellular, systems or translational neuroscience using a range of approaches and strategies. JIN aims to provide a platform for neuroscientists, neurologists, neurobiologists, and related researchers to share emerging knowledge and foster innovation within the scientific community. The journal accepts Original Research Articles, Reviews, Systematic Reviews, Short Communications, Editorials, Opinions, Letters to the Editor and Commentary Articles.

5 Days

Time to First Decision

42 Days

Review Time

87 Days

Submission to Acceptance

P-ISSN: 0219-6352

E-ISSN: 1757-448X

5 Days

Time to First Decision

42 Days

Review Time

87 Days

Submission to Acceptance

Highlights

JIN's Impact Factor Increased to 3.3 in 2025

JIN CiteScore Increased to 5

Acknowledgment to Reviewers of Journal of Integrative Neuroscience in 2025

We are Excited to Announce the Launch of Our New Website!

Advances in Spinal Cord Injury – Insights from AIM-SCI 2025

IMR Press Incorporates STM Integrity Hub into its Manuscript Review Process

Call for Early Career Researcher (ECR) Editorial Board Members - Join Now!

IMR Press becomes Member of STM

JIN is Now a Member of Committee on Publication Ethics (COPE)

Image Integrity Review Tool in IMR Press

JIN's Impact Factor Increased to 3.3 in 2025

JIN CiteScore Increased to 5

Acknowledgment to Reviewers of Journal of Integrative Neuroscience in 2025

We are Excited to Announce the Launch of Our New Website!

Advances in Spinal Cord Injury – Insights from AIM-SCI 2025

IMR Press Incorporates STM Integrity Hub into its Manuscript Review Process

Call for Early Career Researcher (ECR) Editorial Board Members - Join Now!

IMR Press becomes Member of STM

JIN is Now a Member of Committee on Publication Ethics (COPE)

Image Integrity Review Tool in IMR Press

Articles

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Latest Articles

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Funding

Pharmacological Profile of Purinergic P2Y Receptors Involved in Neurogenic Cardiovascular Modulation Induced by ADP and Related Compounds in Rats

Open Access 4 Aug 2026Review

Pharmacological Profile of Purinergic P2Y Receptors Involved in Neurogenic Cardiovascular Modulation Induced by ADP and Related Compounds in Rats

Roberto C. Silva-Velasco, Kristian A. Haanes, Belinda Villanueva-Castillo, Antoinette Maassen van den Brink, Carlos M. Villalón

J. Integr. Neurosci. 2026, 25(8), 51224; https://doi.org/10.31083/JIN51224 (registering DOI)

Abstract

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Age-Dependent Effects of Caffeine on Physiological, Behavioral, and Circadian Gene Changes in Young and Mature C57BL/6 Male Mice

Open Access 3 Aug 2026Original Research

Age-Dependent Effects of Caffeine on Physiological, Behavioral, and Circadian Gene Changes in Young and Mature C57BL/6 Male Mice

Sookyoung Park, Zeeshan Ahmad Khan, AbuZar Ansari, Urala Kalasi Apsara Shamali, Anik Kumar Kar, Yejin Lee, Gwangbae Lee, Jaeyeong Kim, Semin Son, Yonggeun Hong

J. Integr. Neurosci. 2026, 25(8), 46140; https://doi.org/10.31083/JIN46140 (registering DOI)

Abstract

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Chronic CeA^CRH Activation Disrupts Colonic IL-22/Reg3g Signaling and Induces Depression-Associated Microbiome Shifts in Male Mice

Open Access 3 Aug 2026Original Research

Chronic CeA^CRH Activation Disrupts Colonic IL-22/Reg3g Signaling and Induces Depression-Associated Microbiome Shifts in Male Mice

Liaorihong Zhao, Yu Long, Kexin Zeng, Shuya Chen, Tian Qiu, Ou Fu

J. Integr. Neurosci. 2026, 25(8), 48170; https://doi.org/10.31083/JIN48170 (registering DOI)

Abstract

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Anticholinergic Burden and Cognitive Function, Depressive Symptoms, and Functional Performance in Individuals With Neurocognitive Disorders: Real-World Evidence

Open Access 30 Jul 2026Original Research

Anticholinergic Burden and Cognitive Function, Depressive Symptoms, and Functional Performance in Individuals With Neurocognitive Disorders: Real-World Evidence

Maria Skondra, Leonidas Papadopoulos, Theodora Kougioumtzoglou, Charalampos L. Kandilakis, Eleni Konidari, Violeta Papalexiou, Ianthi Marouli, Loukia-Maria Malagkoniari, Andreas Kostakiotis, Theokritos Veskoukis, Vaios Peritogiannis, Polychronis Economou, Panagiotis Felemegkas, Panagiotis Alexopoulos

J. Integr. Neurosci. 2026, 25(7), 51135; https://doi.org/10.31083/JIN51135

(This article belongs to the Special Issue Advances in Depression Research-Volume II)

Abstract

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158

Sevoflurane and Aβ_1-42 Oligomers Synergistically Induce Morphological Changes of Astrocytes in the Hippocampus of Male Mice

Open Access 29 Jul 2026Short Communication

Sevoflurane and Aβ_1-42 Oligomers Synergistically Induce Morphological Changes of Astrocytes in the Hippocampus of Male Mice

Qinfang Shi, Arpit Kumar Pradhan, Siwei Dong, Gerhard Rammes, Xingxing Wang

J. Integr. Neurosci. 2026, 25(7), 50442; https://doi.org/10.31083/JIN50442

Abstract

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124

Sarsasapogenin Improves Pathological Phenotypes in MPTP/MPP⁺-Induced Parkinson’s Disease Models: Synergistic Actions of Neurite Outgrowth, Neurotransmitter Modulation, and Anti-Inflammation

Open Access 29 Jul 2026Original Research

Sarsasapogenin Improves Pathological Phenotypes in MPTP/MPP⁺-Induced Parkinson’s Disease Models: Synergistic Actions of Neurite Outgrowth, Neurotransmitter Modulation, and Anti-Inflammation

Wendi Deng, Jinfeng Hong, Weixia Li, Yi Zhang, Yongping Zhang, Zhiyou Yang

J. Integr. Neurosci. 2026, 25(7), 50683; https://doi.org/10.31083/JIN50683

Abstract

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113

The Efficacy of Experimental Therapy for Stroke Induced by Cerebral Air Embolism in Awake Rats Is Affected by Heliox Inhalation Temperature

Open Access 29 Jul 2026Original Research

The Efficacy of Experimental Therapy for Stroke Induced by Cerebral Air Embolism in Awake Rats Is Affected by Heliox Inhalation Temperature

Arina Kholina, Alina Ismailova, Victor Palikov, Natalya Borozdina, Sergey Kozlov, Olga Patsap, Michael Ignatyuk, Dmitry Rzhevsky, Gulsara Slashcheva, Elvira Shaykhutdinova, Igor Dyachenko, Arkady Murashev, Nikolay Pavlov, Victor Baranov

J. Integr. Neurosci. 2026, 25(7), 51502; https://doi.org/10.31083/JIN51502

Abstract

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Knockdown of Smox Protects Against Cerebral Ischemia/Reperfusion Injury by Suppressing Neuronal Autophagy via the AKT/AMPK/mTOR Phosphorylation Pathway

Open Access 27 Jul 2026Original Research

Knockdown of Smox Protects Against Cerebral Ischemia/Reperfusion Injury by Suppressing Neuronal Autophagy via the AKT/AMPK/mTOR Phosphorylation Pathway

Zhihui Li, Qian Wang, Kaixuan Ma, Mengna Yu, Yanyan Wang, Zhongqiao Ge, Peng Lin, Hui Wang, Lexun Lin, Yang Chen, Lina Jia, Heming Li, Zhongqiu Fu, Zhaohua Zhong, Guangtian Wang

J. Integr. Neurosci. 2026, 25(7), 50711; https://doi.org/10.31083/JIN50711

Abstract

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111

Extracellular Vesicle-Mediated Delivery of VEGF and NGF Protects Dopaminergic Neurons in 6-OHDA-Induced Parkinson’s Disease Models

Open Access 27 Jul 2026Original Research

Extracellular Vesicle-Mediated Delivery of VEGF and NGF Protects Dopaminergic Neurons in 6-OHDA-Induced Parkinson’s Disease Models

Wenyu Yan, Xianyue Meng, Yan Wang, Chuanfei Wei, Fabin Han, Xueli Li

J. Integr. Neurosci. 2026, 25(7), 50932; https://doi.org/10.31083/JIN50932

Abstract

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Brain Functional Alterations Associated With Postural Stability Across the Frailty Continuum: A Resting-State fMRI Study

Open Access 27 Jul 2026Original Research

Brain Functional Alterations Associated With Postural Stability Across the Frailty Continuum: A Resting-State fMRI Study

Sheng Huang, Yongyi Xu, Yaping Li, Shizhu Lin, Xinya Lan, Cai Jiang, Xiaohua Ke, Zhonghua Lin

J. Integr. Neurosci. 2026, 25(7), 51891; https://doi.org/10.31083/JIN51891

Abstract

Download

Latest Articles

Most Read

Funding

Pharmacological Profile of Purinergic P2Y Receptors Involved in Neurogenic Cardiovascular Modulation Induced by ADP and Related Compounds in Rats

Open Access 4 Aug 2026Review

Pharmacological Profile of Purinergic P2Y Receptors Involved in Neurogenic Cardiovascular Modulation Induced by ADP and Related Compounds in Rats

Roberto C. Silva-Velasco, Kristian A. Haanes, Belinda Villanueva-Castillo, Antoinette Maassen van den Brink, Carlos M. Villalón

J. Integr. Neurosci. 2026, 25(8), 51224; https://doi.org/10.31083/JIN51224 (registering DOI)

Abstract

Download

Age-Dependent Effects of Caffeine on Physiological, Behavioral, and Circadian Gene Changes in Young and Mature C57BL/6 Male Mice

Open Access 3 Aug 2026Original Research

Age-Dependent Effects of Caffeine on Physiological, Behavioral, and Circadian Gene Changes in Young and Mature C57BL/6 Male Mice

Sookyoung Park, Zeeshan Ahmad Khan, AbuZar Ansari, Urala Kalasi Apsara Shamali, Anik Kumar Kar, Yejin Lee, Gwangbae Lee, Jaeyeong Kim, Semin Son, Yonggeun Hong

J. Integr. Neurosci. 2026, 25(8), 46140; https://doi.org/10.31083/JIN46140 (registering DOI)

Abstract

Download

Chronic CeA^CRH Activation Disrupts Colonic IL-22/Reg3g Signaling and Induces Depression-Associated Microbiome Shifts in Male Mice

Open Access 3 Aug 2026Original Research

Chronic CeA^CRH Activation Disrupts Colonic IL-22/Reg3g Signaling and Induces Depression-Associated Microbiome Shifts in Male Mice

Liaorihong Zhao, Yu Long, Kexin Zeng, Shuya Chen, Tian Qiu, Ou Fu

J. Integr. Neurosci. 2026, 25(8), 48170; https://doi.org/10.31083/JIN48170 (registering DOI)

Abstract

Download

Anticholinergic Burden and Cognitive Function, Depressive Symptoms, and Functional Performance in Individuals With Neurocognitive Disorders: Real-World Evidence

Open Access 30 Jul 2026Original Research

Anticholinergic Burden and Cognitive Function, Depressive Symptoms, and Functional Performance in Individuals With Neurocognitive Disorders: Real-World Evidence

J. Integr. Neurosci. 2026, 25(7), 51135; https://doi.org/10.31083/JIN51135

(This article belongs to the Special Issue Advances in Depression Research-Volume II)

Abstract

Download

158

Sevoflurane and Aβ_1-42 Oligomers Synergistically Induce Morphological Changes of Astrocytes in the Hippocampus of Male Mice

Open Access 29 Jul 2026Short Communication

Sevoflurane and Aβ_1-42 Oligomers Synergistically Induce Morphological Changes of Astrocytes in the Hippocampus of Male Mice

Qinfang Shi, Arpit Kumar Pradhan, Siwei Dong, Gerhard Rammes, Xingxing Wang

J. Integr. Neurosci. 2026, 25(7), 50442; https://doi.org/10.31083/JIN50442

Abstract

Download

124

Sarsasapogenin Improves Pathological Phenotypes in MPTP/MPP⁺-Induced Parkinson’s Disease Models: Synergistic Actions of Neurite Outgrowth, Neurotransmitter Modulation, and Anti-Inflammation

Open Access 29 Jul 2026Original Research

Sarsasapogenin Improves Pathological Phenotypes in MPTP/MPP⁺-Induced Parkinson’s Disease Models: Synergistic Actions of Neurite Outgrowth, Neurotransmitter Modulation, and Anti-Inflammation

Wendi Deng, Jinfeng Hong, Weixia Li, Yi Zhang, Yongping Zhang, Zhiyou Yang

J. Integr. Neurosci. 2026, 25(7), 50683; https://doi.org/10.31083/JIN50683

Abstract

Download

113

The Efficacy of Experimental Therapy for Stroke Induced by Cerebral Air Embolism in Awake Rats Is Affected by Heliox Inhalation Temperature

Open Access 29 Jul 2026Original Research

The Efficacy of Experimental Therapy for Stroke Induced by Cerebral Air Embolism in Awake Rats Is Affected by Heliox Inhalation Temperature

J. Integr. Neurosci. 2026, 25(7), 51502; https://doi.org/10.31083/JIN51502

Abstract

Download

Knockdown of Smox Protects Against Cerebral Ischemia/Reperfusion Injury by Suppressing Neuronal Autophagy via the AKT/AMPK/mTOR Phosphorylation Pathway

Open Access 27 Jul 2026Original Research

Knockdown of Smox Protects Against Cerebral Ischemia/Reperfusion Injury by Suppressing Neuronal Autophagy via the AKT/AMPK/mTOR Phosphorylation Pathway

Zhihui Li, Qian Wang, Kaixuan Ma, Mengna Yu, Yanyan Wang, Zhongqiao Ge, Peng Lin, Hui Wang, Lexun Lin, Yang Chen, Lina Jia, Heming Li, Zhongqiu Fu, Zhaohua Zhong, Guangtian Wang

J. Integr. Neurosci. 2026, 25(7), 50711; https://doi.org/10.31083/JIN50711

Abstract

Download

111

Extracellular Vesicle-Mediated Delivery of VEGF and NGF Protects Dopaminergic Neurons in 6-OHDA-Induced Parkinson’s Disease Models

Open Access 27 Jul 2026Original Research

Extracellular Vesicle-Mediated Delivery of VEGF and NGF Protects Dopaminergic Neurons in 6-OHDA-Induced Parkinson’s Disease Models

Wenyu Yan, Xianyue Meng, Yan Wang, Chuanfei Wei, Fabin Han, Xueli Li

J. Integr. Neurosci. 2026, 25(7), 50932; https://doi.org/10.31083/JIN50932

Abstract

Download

Brain Functional Alterations Associated With Postural Stability Across the Frailty Continuum: A Resting-State fMRI Study

Open Access 27 Jul 2026Original Research

Brain Functional Alterations Associated With Postural Stability Across the Frailty Continuum: A Resting-State fMRI Study

Sheng Huang, Yongyi Xu, Yaping Li, Shizhu Lin, Xinya Lan, Cai Jiang, Xiaohua Ke, Zhonghua Lin

J. Integr. Neurosci. 2026, 25(7), 51891; https://doi.org/10.31083/JIN51891

Abstract

Download

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Announcements

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Journal Metrics

Metrics

Impact Factor3.3

CiteScore5

Frequency12 issues per year

Establish Year2002

Indexing

SCIE (Web of Science), MEDLINE (PubMed), Scopus, DOAJ

Journal Metrics

Metrics

Impact Factor3.3

CiteScore5

Frequency12 issues per year

Establish Year2002

Indexing

SCIE (Web of Science), MEDLINE (PubMed), Scopus, DOAJ

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Interviews

Special Interview with Francesco Ruggeri: Exploring Retinal Optical Coherence Tomography (OCT) Biomarkers for Neurodegenerative Diseases

Special Interview with Editorial Board Member Dr. Nuno A. Silva: Exploration of New Treatments and Collaborative Paths for Spinal Cord Injury

Interviews

Special Interview with Francesco Ruggeri: Exploring Retinal Optical Coherence Tomography (OCT) Biomarkers for Neurodegenerative Diseases

Special Interview with Editorial Board Member Dr. Nuno A. Silva: Exploration of New Treatments and Collaborative Paths for Spinal Cord Injury

Editorial Board

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Zhong Chen
Editor-in-Chief
brain disorders; epilepsy; stroke; neuropathic pain; histaminergic neurons; histaminergic receptors
Bettina Platt
Editor-in-Chief
brain health; neurodegeneration; dementia; cognition; senescence; translational technologies; EEG; stem cells; inflammation; therapeutics

Editorial Board

Zhong Chen
Editor-in-Chief
brain disorders; epilepsy; stroke; neuropathic pain; histaminergic neurons; histaminergic receptors
Bettina Platt
Editor-in-Chief
brain health; neurodegeneration; dementia; cognition; senescence; translational technologies; EEG; stem cells; inflammation; therapeutics

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