Formyl-CoA transferase
| Formyl-CoA transferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.3.16 | ||||||||
| CAS no. | 128826-27-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Formyl-CoA transferase (EC 2.8.3.16) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme characterised from Oxalobacter formigenes are oxalic acid and formyl-CoA. Its products are oxalyl-CoA and formic acid.[1][2] The kinetics and mechanism of the reaction have been studied.[3][4]
This enzyme is a transferase, specifically a CoA-transferases. The systematic name of this enzyme class is formyl-CoA:oxalate CoA-transferase. Other names in common use include formyl-coenzyme A transferase, and formyl-CoA oxalate CoA-transferase.[5]
Structural studies
[edit]As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1T3Z, PDB: 1T4C, PDB: 1VGQ, and PDB: 1VGR.
References
[edit]- ↑ Baetz AL, Allison MJ (1990). "Purification and characterization of formyl-coenzyme A transferase from Oxalobacter formigenes". J. Bacteriol. 172 (7): 3537–40. doi:10.1128/jb.172.7.3537-3540.1990. PMC 213325. PMID 2361939.
- ↑ Sidhu H, Ogden SD, Lung HY, Luttge BG, Baetz AL, Peck AB (1997). "DNA sequencing and expression of the formyl coenzyme A transferase gene, frc, from Oxalobacter formigenes". J. Bacteriol. 179 (10): 3378–81. doi:10.1128/jb.179.10.3378-3381.1997. PMC 179125. PMID 9150242.
- ↑ Jonsson, Stefan; Ricagno, Stefano; Lindqvist, Ylva; Richards, Nigel G.J. (2004). "Kinetic and Mechanistic Characterization of the Formyl-CoA Transferase from Oxalobacter formigenes". Journal of Biological Chemistry. 279 (34): 36003–36012. doi:10.1074/jbc.M404873200. PMID 15213226.
- ↑ Berthold, Catrine L.; Toyota, Cory G.; Richards, Nigel G.J.; Lindqvist, Ylva (2008). "Reinvestigation of the Catalytic Mechanism of Formyl-CoA Transferase, a Class III CoA-transferase". Journal of Biological Chemistry. 283 (10): 6519–6529. doi:10.1074/jbc.M709353200. PMID 18162462.
- ↑ Enzyme 2.8.3.16 at KEGG Pathway Database.
