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. 2010 Jul;9(7):17-A.

Cholesterol, mood, and vascular health: Untangling the relationship: Does low cholesterol predispose to depression and suicide, or vice versa?

Jess G Fiedorowicz  1 , William G Haynes  2
Affiliations

Cholesterol, mood, and vascular health: Untangling the relationship: Does low cholesterol predispose to depression and suicide, or vice versa?

Jess G Fiedorowicz et al. Curr Psychiatr. 2010 Jul.
No abstract available

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Figures

Figure
Figure. Cholesterol, depression, and suicide: How are they linked?
Low cholesterol may be considered as a trait marker, predisposing patient to lower serotonergic function and placing them at greater risk for impulsivity, depression, aggression, and suicide. Other models suggest the associations are epiphenomenon, a state-dependent consequence of depression, and not part of a causal chain toward suicide.
See this image and copyright information in PMC

References

Source: For references, see this article at CurrentPsychiatry.com

    1. Vevera J, Fisar Z, Kvasnicka T, et al. Cholesterol-lowering therapy evokes time-limited changes in serotonergic transmission. Psychiatry Res. 2005;133(2–3):197–203. - PubMed
    1. Kaplan JR, Shively CA, Fontenot MB, et al. Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Psychosom Med. 1994;56(6):479–484. - PubMed
    1. Chattopadhyay A, Paila YD. Lipid-protein interactions, regulation and dysfunction of brain cholesterol. Biochem Biophys Res Commun. 2007;354(3):627–633. - PubMed
    1. Singh P, Paila YD, Chattopadhyay A. Differential effects of cholesterol and 7-dehydrocholesterol on the ligand binding activity of the hippocampal serotonin(1A) receptor: implications in SLOS. Biochem Biophys Res Commun. 2007;358(2):495–499. - PubMed
    1. Sjögren B, Hamblin MW, Svenningsson P. Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. Eur J Pharmacol. 2006;552(1–3):1–10. - PubMed

References

    1. Osby U, Brandt L, Correia N, et al. Excess mortality in bipolar and unipolar disorder in Sweden. Arch Gen Psychiatry. 2001;58(9):844–850. - PubMed
    1. Lindberg G, Råstam L, Gullberg B, et al. Low serum cholesterol concentration and short term mortality from injuries in men and women. BMJ. 1992;305(6848):277–279. - PMC - PubMed
    1. Muldoon MF, Manuck SB, Matthews KA. Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials. BMJ. 1990;301(6747):309–314. - PMC - PubMed
    1. Neaton JD, Blackburn H, Jacobs D, et al. Serum cholesterol level and mortality findings for men screened in the Multiple Risk Factor Intervention Trial. Multiple Risk Factor Intervention Trial Research Group. Arch Intern Med. 1992;152(7):1490–1500. - PubMed
    1. Fiedorowicz JG, Coryell WH. Cholesterol and suicide attempts: a prospective study of depressed inpatients. Psychiatry Res. 2007;152(1):11–20. - PMC - PubMed

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