The identity and function of microglia in neurodegeneration

Song, Wilbur M.; Colonna, Marco

doi:10.1038/s41590-018-0212-1

Nat Immunol

2018

DOI: 10.1038/s41590-018-0212-1

|Get access via publisher |Summarize |Cite

|

Sign up to set email alerts

The identity and function of microglia in neurodegeneration

Wilbur M. Song

¹

,

Marco Colonna

²

Help me understand this report

Cited by 329 publications

(291 citation statements)

References 177 publications

Supporting

7

Mentioning

284

Contrasting

0

Unclassified

0

Order By: Relevance

“…MG showed the strongest transcriptional change (more DEGs, affected pathways, and activated diseases) than the two neuron types. This result is consistent with most previous studies, indicating that MG is one of the most sensitive cell types in mediating cognitive defects and neurodegeneration. − Microglia phagocytose cell debris and overproduce synapses under normal conditions, which facilitates the structural and functional recovery of impaired tissues. , Alternatively, microglia exhibit misdirected or excessive phagocytosis of normal neurons under pathological conditions, , which subsequently exacerbates brain injury. Evidence suggests that this detrimental form of phagocytosis of microglia may be attributed to inflammation or a subtoxic insult. , In the present study, after the functional analysis of DEGs in microglia, we identified significant activation of phagocytosis, neuronal apoptosis, and neuronal cell death processes after 0.5 μg/L BPF exposure.…”

Section: Discussionsupporting

confidence: 92%

Bisphenol F Impaired Zebrafish Cognitive Ability through Inducing Neural Cell Heterogeneous Responses

Mu

¹

,

Liu

²

,

Wang

³

et al. 2022

Environ. Sci. Technol.

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…MG showed the strongest transcriptional change (more DEGs, affected pathways, and activated diseases) than the two neuron types. This result is consistent with most previous studies, indicating that MG is one of the most sensitive cell types in mediating cognitive defects and neurodegeneration. − Microglia phagocytose cell debris and overproduce synapses under normal conditions, which facilitates the structural and functional recovery of impaired tissues. , Alternatively, microglia exhibit misdirected or excessive phagocytosis of normal neurons under pathological conditions, , which subsequently exacerbates brain injury. Evidence suggests that this detrimental form of phagocytosis of microglia may be attributed to inflammation or a subtoxic insult. , In the present study, after the functional analysis of DEGs in microglia, we identified significant activation of phagocytosis, neuronal apoptosis, and neuronal cell death processes after 0.5 μg/L BPF exposure.…”

Section: Discussionsupporting

confidence: 92%

Bisphenol F Impaired Zebrafish Cognitive Ability through Inducing Neural Cell Heterogeneous Responses

Mu

¹

,

Liu

²

,

Wang

³

et al. 2022

Environ. Sci. Technol.

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…4e). These results reflect that microglia and excitatory neurons are the primary cell types contributing to genetic risk for AD and SCZ, respectively, which is supported by the literature of AD and SCZ 28, 29 .…”

Section: Resultssupporting

confidence: 85%

“…4e). These results reflect that microglia and excitatory neurons are the primary cell types contributing to genetic risk for AD and SCZ, respectively, which is supported by the literature of AD and SCZ 28,29 . Subsequently, we select the genes regulated by the cell-type-specific CRRs related to SCZ or AD to perform gene ontology (GO) enrichment analysis.…”

Section: Script Understands the Pathogenic Mechanisms Of Ad And Scz I...supporting

confidence: 85%

SCRIPT: predicting single-cell long-range cis -regulation based on pretrained graph attention networks

Zhang

¹

,

Liu

²

,

Xu

³

et al. 2025

Preprint

0

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Of note, the induced expression of MHCII (H2-Aa) was also confirmed on the protein level in mice and in human CNV membranes (Wieghofer et al, in press). The observed increase of Apoe expression further supports the induction of the DAM gene expression signature mediated by binding to the triggering receptor of myeloid cells 2 (TREM2), like it was shown in the brain (Song and Colonna, 2018). Furthermore, Apoe was highly expressed in DAM in a model of retinal light damage and, most importantly, in mononuclear phagocytes in the subretinal space in AMD patients (Levy et al, 2015a,b;O'Koren et al, 2019).…”

Section: Discussionsupporting

confidence: 58%

Secreted Phosphoprotein 1 Expression in Retinal Mononuclear Phagocytes Links Murine to Human Choroidal Neovascularization

Schlecht

¹

,

Zhang

²

,

Wolf

³

et al. 2021

Front. Cell Dev. Biol.

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA