Just above Chance: Is It Harder to Decode Information from Prefrontal Cortex Hemodynamic Activity Patterns?

Bhandari, Apoorva; Gagne, Chris; Badre, David

doi:10.1162/jocn_a_01291

Journal of Cognitive Neuroscience

2018

DOI: 10.1162/jocn_a_01291

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Just above Chance: Is It Harder to Decode Information from Prefrontal Cortex Hemodynamic Activity Patterns?

Apoorva Bhandari

¹

,

Chris Gagne

²

,

David Badre

³

Abstract: The prefrontal cortex (PFC) is central to flexible, goal-directed cognition, and understanding its representational code is an important problem in cognitive neuroscience. In humans, multivariate pattern analysis (MVPA) of fMRI blood oxygenation level-dependent (BOLD) measurements has emerged as an important approach for studying neural representations. Many previous studies have implicitly assumed that MVPA of fMRI BOLD is just as effective in decoding information encoded in PFC neural activity as it is in vi… Show more

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Cited by 90 publications

(82 citation statements)

References 162 publications

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“…4d). These findings are consistent with previous studies that have found that higher-order association areas typically have relatively low decoding accuracies, even for tasks that heavily involve those regions 38 .…”

Section: Network Topography Of Ra Relates To the Brain's Intrinsic Organizationsupporting

confidence: 93%

Multi-task representations in human cortex transform along a sensory-to-motor hierarchy

Ito

¹

,

Murray

²

2021

Preprint

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…4d). These findings are consistent with previous studies that have found that higher-order association areas typically have relatively low decoding accuracies, even for tasks that heavily involve those regions 38 .…”

Section: Network Topography Of Ra Relates To the Brain's Intrinsic Organizationsupporting

confidence: 93%

Multi-task representations in human cortex transform along a sensory-to-motor hierarchy

Ito

¹

,

Murray

²

2021

Preprint

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The use of catch trials ensured that the cue and stimulus GLM regressors were appropriately decorrelated. The overall classification accuracies in our data were low, similarly to previous studies that used MVPA for fMRI data across the frontoparietal cortex (Erez & Duncan, 2015;Nelissen, Stokes, Nobre, & Rushworth, 2013;Soon, Brass, Heinze, & Haynes, 2008;, and this may be possibly related to the functional organization at the neuronal population level (Bhandari, Gagne, & Badre, 2018;Dubois, de Berker, & Tsao, 2015).…”

Section: Discussionsupporting

confidence: 80%

Reward motivation increases univariate activity but has limited effect on coding of task-relevant information across the frontoparietal cortex

Shashidhara,

Erez

2019

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2

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…While our classification accuracies were relatively low, similar levels of performance have been commonly reported when examining goal representation across MDN (Waskom et al, 2014;Erez and Duncan, 2015;Bhandari et al, 2018).…”

Section: Discussionsupporting

confidence: 78%

Both Default and Multiple-Demand Regions Represent Semantic Goal Information

Wang

¹

,

Gao

²

,

Smallwood

³

et al. 2021

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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