Autophagy and innate immunity: Insights from invertebrate model organisms

Kuo, Cheng‐Ju; Hansen, Malene; Troemel, Emily R.

doi:10.1080/15548627.2017.1389824

Autophagy

2018

DOI: 10.1080/15548627.2017.1389824

|Get access via publisher |Summarize |Cite

|

Sign up to set email alerts

Autophagy and innate immunity: Insights from invertebrate model organisms

Cheng‐Ju Kuo

¹

,

Malene Hansen

²

,

Emily R. Troemel

³

Abstract: Macroautophagy/autophagy is a fundamental intracellular degradation process with multiple roles in immunity, including direct elimination of intracellular microorganisms via 'xenophagy.' In this review, we summarize studies from the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans that highlight the roles of autophagy in innate immune responses to viral, bacterial, and fungal pathogens. Research from these genetically tractable invertebrates has uncovered several conserved immunologica… Show more

Help me understand this report

Cited by 170 publications

(113 citation statements)

References 54 publications

Supporting

1

Mentioning

112

Contrasting

0

Unclassified

0

Order By: Relevance

“…The network therefore implicates protein A in roles in the regulation of mRNA processing from expression to translation, and given the quantitatively strong response (Table 1), we hypothesise that the role is critical to the abiotic stress response. In addition, coiled-coil type proteins have previously been shown to have a role in the regulation of gene expression, notably as transcription factors [55,56,57], and this again is consistent with a role in the rapid transcriptional reprogramming in response to stress. The fact that protein A also contains a cwf18 pre-mRNA splicing factor (pfam08315) domain further supports a role in the reprograming of stress-induced transcriptional activities.…”

Section: Discussionsupporting

confidence: 63%

Early Responses to Severe Drought Stress in the Arabidopsis thaliana Cell Suspension Culture Proteome

Alqurashi

¹

,

Chiapello

²

,

Bianchet³

et al. 2018

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The network therefore implicates protein A in roles in the regulation of mRNA processing from expression to translation, and given the quantitatively strong response (Table 1), we hypothesise that the role is critical to the abiotic stress response. In addition, coiled-coil type proteins have previously been shown to have a role in the regulation of gene expression, notably as transcription factors [55,56,57], and this again is consistent with a role in the rapid transcriptional reprogramming in response to stress. The fact that protein A also contains a cwf18 pre-mRNA splicing factor (pfam08315) domain further supports a role in the reprograming of stress-induced transcriptional activities.…”

Section: Discussionsupporting

confidence: 63%

Early Responses to Severe Drought Stress in the Arabidopsis thaliana Cell Suspension Culture Proteome

Alqurashi

¹

,

Chiapello

²

,

Bianchet³

et al. 2018

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“… 18 , 19 Inhibited or excessive autophagy can induce diseases by interacting with apoptosis, inflammation, and immunity. 20 , 21 , 22 Our study revealed an increased expression of the autophagosome marker LC3 in MRONJ gingival epithelium. Autophagy is a dynamic process with three stages, including autophagosome formation, fusion of autophagosomes and lysosomes, and degradation.…”

Section: Discussionmentioning

confidence: 50%

Prevention of medication-related osteonecrosis of the jaw in mice by adipose-derived stem cells associated with activated autophagic flux

Dong

¹

,

Chen

²

,

He

³

et al. 2024

Journal of Dental Sciences

4

0

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…When sonocatalytic nanodrugs are introduced into tumor cells, US stimulation results in mitochondrial damage, leading to a decreased cellular energy supply and triggering autophagy within the cells. This process involves the formation of autophagosomes that degrade toxic proteins and damaged mitochondria . In our study, As the nanodrug was incorporated into lysosomes, the BP on its surface was converted into PO 4 3– ions in the acidic environment.…”

Section: Resultsmentioning

confidence: 78%

“…This process involves the formation of autophagosomes that degrade toxic proteins and damaged mitochondria. 10 In our study, As the nanodrug was incorporated into lysosomes, the BP on its surface was converted into PO 4 3− ions in the acidic environment. The PO 4…”

Section: Synthesis and Characterization Of Bto/bp-hamentioning

confidence: 73%

Sonocatalysis Regulates Tumor Autophagy for Enhanced Immunotherapy

Fu

¹

,

He

²

,

Wei

³

et al. 2024

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA