Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses

Bouhlal, Sofia; Ellefsen, Kayla N.; Sheskier, Mikela B.; Singley, Erick; Pirard, Sandrine; Gorelick, David A.; Huestis, Marilyn A.; Leggio, Lorenzo

doi:10.1016/j.drugalcdep.2017.07.033

Drug and Alcohol Dependence

2017

DOI: 10.1016/j.drugalcdep.2017.07.033

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Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses

Sofia Bouhlal

¹

,

Kayla N. Ellefsen

²

,

Mikela B. Sheskier

³

et al.

Abstract: Background Food intake and use of drugs of abuse like cocaine share common central and peripheral physiological pathways. Appetitive hormones play a major role in regulating food intake; however, little is known about the effects of acute cocaine administration on the blood concentrations of these hormones in cocaine users. Methods We evaluated serum concentrations of six appetitive hormones: ghrelin (total and acyl-ghrelin), amylin, glucagon-like peptide-1 (GLP-1), insulin, leptin and peptide YY (PYY), as w… Show more

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Cited by 49 publications

(41 citation statements)

References 65 publications

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“…Type 1 diabetes subjects who used alcohol also had higher rates of acute pancreatitis, but this effect may have been driven by the presence of DKA or alternatively through previously described mechanisms of alcoholic pancreatitis ( 34 ). Chronic exocrine changes were more commonly seen in type 1 diabetes donors who used cocaine, which could potentially be explained by cocaine’s vasoconstrictive and atherosclerotic properties and is corroborated by previous findings of reduced exocrine pancreatic function in the setting of cocaine use ( 12 , 35 , 36 ). However, current versus past cocaine use was not able to be elucidated.…”

Section: Discussionsupporting

confidence: 83%

Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies

Bruggeman

¹

,

Campbell‐Thompson

²

,

Filipp

³

et al. 2021

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Type 1 diabetes subjects who used alcohol also had higher rates of acute pancreatitis, but this effect may have been driven by the presence of DKA or alternatively through previously described mechanisms of alcoholic pancreatitis ( 34 ). Chronic exocrine changes were more commonly seen in type 1 diabetes donors who used cocaine, which could potentially be explained by cocaine’s vasoconstrictive and atherosclerotic properties and is corroborated by previous findings of reduced exocrine pancreatic function in the setting of cocaine use ( 12 , 35 , 36 ). However, current versus past cocaine use was not able to be elucidated.…”

Section: Discussionsupporting

confidence: 83%

Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies

Bruggeman

¹

,

Campbell‐Thompson

²

,

Filipp

³

et al. 2021

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Only two studies assessed drugs of abuse and GLP-1 in humans. The one study on cocaine showed that GLP-1 levels were significantly reduced after cocaine injections in cocaine users, which might be precipitating further cocaine intake, and subjective “anxiety” was a positive predictor of post-cocaine GLP-1 concentrations (Bouhlal et al, 2017 ). Another study on alcohol use disorder (AUD) found that 168Ser allele (rs6923761) was associated with AUD in humans.…”

Section: Resultsmentioning

confidence: 99%

Can GLP-1 Be a Target for Reward System Related Disorders? A Qualitative Synthesis and Systematic Review Analysis of Studies on Palatable Food, Drugs of Abuse, and Alcohol

Eren

¹

,

Yigit

²

,

Dogruoz

³

et al. 2021

Front. Behav. Neurosci.

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…A pilot study of human cocaine users showed that intravenous cocaine self-administration decreased serum GLP-1 levels, effects associated with cocaine-related cardiorespiratory and subjective responses ( 25 ). While it is not clear how decreased serum GLP-1 may promote the subjective experiences of cocaine in humans, these results suggest that reduced GLP-1 signaling may drive ongoing cocaine taking.…”

Section: Discussionmentioning

confidence: 99%

“…These findings indicate that cocaine taking and subsequent abstinence have differential effects on peripheral versus central GLP-1 expression. Therefore, it is also possible that reduced peripheral GLP-1 expression contributes to the subjective effects of cocaine and promotes drug taking, while increased central GLP-1 signaling fucntions as a compensatory response to reduce ongoing drug taking ( 25 ). Disentangling the roles of peripheral and central GLP-1 signaling in cocaine-mediated behaviors is an important future direction of the lab.…”

Section: Discussionmentioning

confidence: 99%

An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking

Merkel

¹

,

Hernandez

²

,

Weir

³

et al. 2025

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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