Reappraising striatal D1- and D2-neurons in reward and aversion

Soares‐Cunha, Carina; Coimbra, Bárbara; Sousa, Nuno; Rodrigues, Ana João

doi:10.1016/j.neubiorev.2016.05.021

Neuroscience & Biobehavioral Reviews

2016

DOI: 10.1016/j.neubiorev.2016.05.021

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Reappraising striatal D1- and D2-neurons in reward and aversion

Carina Soares‐Cunha

¹

,

Bárbara Coimbra

²

,

Nuno Sousa

³

et al.

Abstract: The striatum has been involved in complex behaviors such as motor control, learning, decision-making, reward and aversion. The striatum is mainly composed of medium spiny neurons (MSNs), typically divided into those expressing dopamine receptor D1, forming the so-called direct pathway, and those expressing D2 receptor (indirect pathway). For decades it has been proposed that these two populations exhibit opposing control over motor output, and recently, the same dichotomy has been proposed for valenced behavio… Show more

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Cited by 191 publications

(164 citation statements)

References 274 publications

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“…Consequently, the MC4R-cre mouse line is an attractive tool to selectively target atypical D1-neurons of the LSS. Whereas the MC4-LSS neurons were atypical at the transcriptional level, our optogenetics findings indicate that their behavioral function is similar to that of typical D1 neurons in that activation is rewarding and induces locomotion (Cole et al, 2018;Kravitz et al, 2010;Soares-Cunha et al, 2016). This contrasts the previous finding that activation of Tshz1-expressing cells (another marker of atypical D1-neurons) in the striosomes in the dorsal striatum was aversive (Xiao et al, 2020).…”

Section: Discussioncontrasting

confidence: 97%

Melanocortin 4 receptor-expressing neurons in the lateral stripe of the striatum are involved in affect regulation and motor control

Sköld

¹

,

Lazzarino

²

,

Nett

³

et al. 2024

Preprint

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Consequently, the MC4R-cre mouse line is an attractive tool to selectively target atypical D1-neurons of the LSS. Whereas the MC4-LSS neurons were atypical at the transcriptional level, our optogenetics findings indicate that their behavioral function is similar to that of typical D1 neurons in that activation is rewarding and induces locomotion (Cole et al, 2018;Kravitz et al, 2010;Soares-Cunha et al, 2016). This contrasts the previous finding that activation of Tshz1-expressing cells (another marker of atypical D1-neurons) in the striosomes in the dorsal striatum was aversive (Xiao et al, 2020).…”

Section: Discussioncontrasting

confidence: 97%

Melanocortin 4 receptor-expressing neurons in the lateral stripe of the striatum are involved in affect regulation and motor control

Sköld

¹

,

Lazzarino

²

,

Nett

³

et al. 2024

Preprint

0

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Furthermore, neither systemic nor accumbal mGluR5 or presynaptic CB1R blockade led to a further decrease in D1 miR mGluR5 mutants (Figure 1, S2, and S3). This suggests that eCB-LTD in D2-MSNs plays no or only a minor role in the processing of reward-seeking responses, which is also in line with previous studies (Calipari et al, 2016;Hikida et al, 2010;Lobo and Nestler, 2011;Ma et al, 2018;Soares-Cunha et al, 2016).…”

Section: Discussionsupporting

confidence: 91%

Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior

Bilbao

¹

,

Neuhofer

²

,

Sepers

³

et al. 2020

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…For example, plasticity in the nucleus accumbens has been hypothesized to be the process and brain region that underlies the formation of the maternal-infant bond ( Atzil et al 2017 ; Gholampour et al 2020 ). In agreement with studies of non-social stimuli ( Calipari et al 2016 ; Baimel et al 2019 ; Soares-Cunha et al 2016 ; 2018 ; 2020 ), this review supports the hypothesis that it is the balance of activity between D1-MSNs and D2-MSNs in the nucleus accumbens that regulates reward and aversion for social interactions.…”

Section: Discussionsupporting

confidence: 87%

The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents

Borland

¹

2024

Neuroscience & Biobehavioral Reviews

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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