During the Cretaceous, diversifications and turnovers affected terrestrial vertebrates experiencing the effects of global geographical change. However, the poor fossil record from the early Late Cretaceous has concealed how dinosaurs and other terrestrial vertebrates responded to these events. I describe two dinosaurs from the Santonian to Early Campanian of the obscure North American paleolandmass Appalachia. A revised look at a large, potentially novel theropod shows that it likely belongs to a new clade of tyrannosauroids solely from Appalachia. Another partial skeleton belongs to an early member of the Hadrosauridae, a highly successful clade of herbivorous dinosaurs. This skeleton is associated with the first small juvenile dinosaur specimens from the Atlantic Coastal Plain. The tyrannosauroid and hadrosaurid substantiate one of the only Late Santonian dinosaur faunas and help pinpoint the timing of important anatomical innovations in two widespread dinosaur lineages. The phylogenetic positions of the tyrannosauroid and hadrosaurid show Santonian Appalachian dinosaur faunas are comparable to coeval Eurasian ones, and the presence of clades formed only by Appalachian dinosaur taxa establishes a degree of endemism in Appalachian dinosaur assemblages attributable to episodes of vicariance.