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Review
. 2015 Jun 25:6:645.
doi: 10.3389/fmicb.2015.00645. eCollection 2015.

Regulation of adaptive immune responses by guiding cell movements in the spleen

Lintao Zhao  1 , Lina Liu  1 , Bo Guo  2 , Bo Zhu  1
Affiliations
Review

Regulation of adaptive immune responses by guiding cell movements in the spleen

Lintao Zhao et al. Front Microbiol. .

Abstract

The spleen combines the innate and adaptive immune systems in a uniquely organized way. The excision of spleen will induce many complications, especially the increased susceptibility to infections. Recent research shows that besides playing roles during the immune responses, the spleen is also an important organ during immunoregulation, which is different from other secondary lymphoid organs. This unique function is mainly realized by modulating cell migration and proliferation in the spleen. This review provides a better understanding of the functions of this complex organ gained from recent studies.

Keywords: CCL21; T cells; cell migration; immunoregulation; spleen.

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Figures

FIGURE 1
FIGURE 1
Migration of different types of cells in the spleen. (A) Spleen cryostat sections from C57BL/6 mice were stained for ER-TR7 (green), and imaged using confocal microscopy (Scale bars: 250 μm); (B) a higher magnification of spleen cryostat sections were observed; (C) different cell components in the blood enter the marginal sinus, and diffuse to the marginal zone. T and B cells will first arrive at the T cell zone. Then follicular Th cells and B cells would move further to the B cell zone. Moreover, B cells also could shuttle continually between the MZ and follicles. The dendritic cells, after reactivation, could enter the T cell zone. MDSCs could be attracted by CCL2 and retained in the MZ and red pulp. Besides, adhesion molecule VCAM-1in red pulp could retain bone marrow HSPCs.
See this image and copyright information in PMC

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