On Thursday, May 14, 2026, the NIDA IRP Clinical Program welcomed representatives from the Office of the Lieutenant Governor. Aruna Miller and her staff received a tour of our facilities and learned about the cutting edge research we are conducting in the field of addiction medicine.
Hot Off the Press
Hippocampal output suppresses orbitofrontal cortex schema cell formation
Hot Off the Press – August 21, 2025 Published in Nature Neuroscience by Wenhui Zong and Geoffrey Schoenbaum, et al. of the NIDA IRP Behavioral Neurophysiology Neuroscience Section. Summary The orbitofrontal cortex (OFC) and hippocampus (HC) are both thought to contribute to the construction of cognitive maps and their generalization into schemas, yet the nature… [Read More]
Reviews To Read
Morphinan Alkaloids and Their Transformations: A Historical Perspective of a Century of Opioid Research in Hungary
Reviews To Read – July 2025. Published in International Journal of Molecular Sciences with contributions by Kenner Rice of the NIDA IRP Drug Design and Synthesis Section. The word opium derives from the ancient Greek word ὄπιον (ópion) for the juice of any plant, but today means the air-dried seed capsule latex of Papaver somniferum. Alkaloid… [Read More]
Featured Papers
Potentiation of fentanyl-induced respiratory depression by alcohol is not fully reversed by naloxone
Featured Paper of the Month – June 2026
Published in JCI Insight by Lyndsay Hastings*, Emma Frye*, Renata Marchette and George Koob of the NIDA IRP Neurobiology of Addiction Section.
In this study, we found that combining fentanyl and alcohol led to reductions in minute ventilation and severe apnea that were not fully reversed by naloxone.
