Cyclic GMP phosphodiesterase and guanylate cyclase activities in rabbit ovaries and the effect of in-vivo stimulation with LH

V. V. Patwardhan; A. Lanthier

doi:10.1677/joe.0.1010305

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Cyclic GMP phosphodiesterase and guanylate cyclase activities in rabbit ovaries and the effect of in-vivo stimulation with LH

in Journal of Endocrinology

Authors:

V. V. Patwardhan

V. V. Patwardhan
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A. Lanthier

A. Lanthier
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DOI:: https://doi.org/10.1677/joe.0.1010305

Volume/Issue:: Volume 101: Issue 3

Article Type:: Research Article

Page Range:: 305–310

Online Publication Date:: Jun 1984

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ABSTRACT

The activities of guanylate cyclase and cyclic GMP (cGMP) phosphodiesterase, enzymes that are responsible for maintaining tissue levels of cGMP, were determined in the ovaries of rabbits killed without treatment or 4 h after administration of LH. Ovarian activities of the two enzymes were determined in the 100 000 g supernatant fraction (cytosol) and the resulting pellet (particulate fraction). Significant phosphodiesterase and cyclase activities were detected in both the cytosol and particulate fractions. Administration of LH had no significant effect on phosphodiesterase activity in either of the tissue fractions. On the other hand, LH caused a significant drop in guanylate cyclase activity in the cytosol and particulate fractions. This drop in the cyclase activity may be the cause of the decreased rabbit ovarian concentrations of cGMP that we have previously observed after LH stimulation.

J. Endocr. (1984) 101, 305–310

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Print ISSN:: 0022-0795

Online ISSN:: 1479-6805

Page(s):: 6

Article Type:: Research Article

Print Publication Date:: 01 Jan 1984

Online Publication Date:: Jun 1984

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Cyclic GMP phosphodiesterase and guanylate cyclase activities in rabbit ovaries and the effect of in-vivo stimulation with LH

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