Tim Sandle

The University of Manchester, Pharmacy and Pharmaceutical Sciences, Adjunct

Dr. Sandle has over twenty-five years experience of microbiological research and biopharmaceutical processing. This includes experience of designing, validating and operating a range of microbiological tests including sterility testing, bacterial endotoxin testing, bioburden and microbial enumeration, environmental monitoring, particle counting and water testing. In addition, Dr. Sandle is experienced in pharmaceutical microbiological risk assessment and investigation.

Dr. Sandle is a tutor with the School of Pharmacy and Pharmaceutical Sciences, University of Manchester for the university’s pharmaceutical microbiology MSc course. In addition, Dr. Sandle serves on several national and international committees relating to pharmaceutical microbiology and cleanroom contamination control (including the ISO cleanroom standards). He is a committee member of the Pharmaceutical Microbiology Interest Group (Pharmig); and is a member of several editorials boards for scientific journals. He was a member of the National Blood Service advisory cleaning and disinfection committee.

Dr. Sandle has acted as a consultant, expert witness and technical advisor to sterile and non-sterile manufacturing facilities, microbiology laboratories, the medical device industry and hospitals. Dr. Sandle has also undertaken several technical writing and review projects.

Dr. Sandle has written over three hundred book chapters, peer reviewed papers and technical articles relating to microbiology. In addition, Dr. Sandle has written several books including "Sterility Testing of Pharmaceutical Products", "Risk Management and Risk Assessment for Pharmaceutical Manufacturing: A contamination control perspective" and "Sterility, Sterilisation and Sterility Assurance for Pharmaceuticals: Technology, Validation and Current Regulations". Dr. Sandle has also edited the book "The CDC Handbook: A Guide to Cleaning and Disinfecting Cleanrooms"; and co-editing the comprehensive books "Microbiology and Sterility Assurance in Pharmaceuticals and Medical Devices" and "Cleanroom Management in Pharmaceuticals and Healthcare". Dr. Sandle has also delivered papers to over fifty international conferences.
Address: BPL, Dagger Lane, Elstree, Herts. WD6 3BX. UK

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Videos

06:43

Top ten facts about cleanrooms

Dr. Tim Sandle presents ten interesting facts about cleanrooms is just 5 minutes!

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03:24

Face masks- the golden rules

How not to wear a face mask - key safety tips with Tim Sandle.

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Books

Antimicrobials: Past, Present, and Future

Antimicrobials: Past, Present, and Future, 2022

A major theme is antimicrobial agents (and the role played by pharmaceutical microbiologists in d... more A major theme is antimicrobial agents (and the role played by pharmaceutical microbiologists in developing and delivering these agents) and the growth in microbial resistance. In the last two decades, the rate at which bacteria are becoming resistant to current antibiotic treatments has substantially increased. This trend is threatening the ability of medical staff to carry out routine operations or transplants in the future. This has been compounded not only by microorganisms that are resistant to one antimicrobial or another, but due to the rise of multi-drug resistant microorganisms (the so-termed ‘super bugs’).

The book traces the development of antimicrobials and contextualises the different types that are available. Later the text looks at how natural and synthetic antibacterial agents work and describes the problems that resistance present for the next generation of scientists who will be required to develop new and more effective treatments. For the generation of alternatives, an understanding of biotechnology is required and hence this subject area represents another major theme considered throughout the text.

Laboratory methods in the screening of viral C hepatitis

Laboratory methods, 2021

The study aimed to manage and to analyse the results of the laboratory tests, available nowadays,... more The study aimed to manage and to analyse the results of the laboratory tests, available nowadays, used from routine clinical practice, for screening of hepatitis C. Methods: comparison of ELISA method results (Enzyme-Linked Immunosorbent Assay) and chemiluminescence methods results. Beside previously mentioned, the study show the structural comparison of normal liver and pathologic liver with hepatic cirrhosis, using permanent samples colored after the technique protocol. Statistical analysis of this study results, was performed using the laboratory informatic system. Results: The results of the study are substantial and intricate. For this purpose, the results of preliminary EСL screening method of patients at risk for HCV who took part in the study, are presented in tables and figures. Results of this study are various and are correlate from different perspectives. Also good to mention that the correlations of results were used in order to identify a possible relationships between indicators of ELISA method and ECL index. More than, correlations antibodies detected in ECL and ELISA are point out.

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Tim Sandle

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