Nebulised hypertonic saline solution for acute bronchiolitis in infants

“…As shown by previous systematic reviews 5,7 and this metaanalysis, nebulized HS has good safety profile with minor adverse effects in infants with acute bronchiolitis. Worsening of cough was the most frequently reported adverse event, but it is generally mild and self-limiting, and no intervention or additional treatment is necessary.…”

“…Those larger RCTs referenced but excluded from analysis in the Cochrane review also showed improvements in clinical severity scores [47–49]. The justifications presented, variation in scoring methods and assessment time points, could readily have been dealt with using Cochrane's described methodologies [39, 41]. Other meta‐analyses did include these outpatient RCTs in their meta‐analyses [43, 44, 46].…”

“…Nine of 11 meta‐analyses reported a decrease in admissions following outpatient treatment with HTS [33, 39–46]. Seven of 11 studies reported improvements in outpatient clinical severity scores [37–39, 41, 43–45].…”

“…Acute bronchiolitis is a common cause of hospitalization and morbidity in infancy ( 58 ). The mainstay of therapy for acute bronchiolitis includes airway support, gentle nasal suctioning, fluid administration, and adequate nutrition ( 58 , 59 ).…”

“…As shown by previous systematic reviews 5,7 and this metaanalysis, nebulized HS has good safety profile with minor adverse effects in infants with acute bronchiolitis. Worsening of cough was the most frequently reported adverse event, but it is generally mild and self-limiting, and no intervention or additional treatment is necessary.…”

“…Those larger RCTs referenced but excluded from analysis in the Cochrane review also showed improvements in clinical severity scores [47–49]. The justifications presented, variation in scoring methods and assessment time points, could readily have been dealt with using Cochrane's described methodologies [39, 41]. Other meta‐analyses did include these outpatient RCTs in their meta‐analyses [43, 44, 46].…”

“…Nine of 11 meta‐analyses reported a decrease in admissions following outpatient treatment with HTS [33, 39–46]. Seven of 11 studies reported improvements in outpatient clinical severity scores [37–39, 41, 43–45].…”

“…Acute bronchiolitis is a common cause of hospitalization and morbidity in infancy ( 58 ). The mainstay of therapy for acute bronchiolitis includes airway support, gentle nasal suctioning, fluid administration, and adequate nutrition ( 58 , 59 ).…”

“…As shown by previous systematic reviews 5,7 and this metaanalysis, nebulized HS has good safety profile with minor adverse effects in infants with acute bronchiolitis. Worsening of cough was the most frequently reported adverse event, but it is generally mild and self-limiting, and no intervention or additional treatment is necessary.…”

“…Those larger RCTs referenced but excluded from analysis in the Cochrane review also showed improvements in clinical severity scores [47–49]. The justifications presented, variation in scoring methods and assessment time points, could readily have been dealt with using Cochrane's described methodologies [39, 41]. Other meta‐analyses did include these outpatient RCTs in their meta‐analyses [43, 44, 46].…”

“…Nine of 11 meta‐analyses reported a decrease in admissions following outpatient treatment with HTS [33, 39–46]. Seven of 11 studies reported improvements in outpatient clinical severity scores [37–39, 41, 43–45].…”

“…Acute bronchiolitis is a common cause of hospitalization and morbidity in infancy ( 58 ). The mainstay of therapy for acute bronchiolitis includes airway support, gentle nasal suctioning, fluid administration, and adequate nutrition ( 58 , 59 ).…”