2016
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The role of silver sulphadiazine in the conservative treatment of partial thickness burn wounds: A systematic review
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Cited by 116 publications
(61 citation statements)
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Abstract
Smart CitationsHow this paper cites the one you are viewing
“…As for the sulfadizine-treated group, previous studies also endorse the above observation, showing that silver sulfadizine not only has antimicrobial properties, but can also modulate the inflammatory response [10], through its interaction with proteins and enzymes within immune cells, especially macrophages, affecting signalling pathways crucial for the transcription of proinflammatory genes, such as TNFα, involving the modulation of transcription factors such as NF-κβ, which plays a central role in regulating TNFα expression [49]. This would explain why the application of sulfadizine to burns reduced the expression of TNFα, leading to more effective healing of these lesions [50].…”
Section: Discussion
supporting
confidence: 54%
“…Pro-inflammatory cellular activity, especially of neutrophils and the release of cytokines, as discussed above, also contribute to the formation of ROS and NROS, which eventually lead to lipoperoxidation, which in turn contributes to greater tissue degeneration at the site of injury, due to the increased concentration of MDAs since cell membranes are rich in polyunsaturated fatty acids, a vulnerable target for ROS [2,38]. Thus, we found that there was a gradual reduction in the concentration of enzymes of the antioxidant system, SOD and CAT and in the evaluation of both enzymes, the most significant reduction in their expression occurred in groups SUL + PBM and SER + PBM, possibly because these groups, due to the combination of treatments, were led to an early maturation of the injured tissue, already transitioning from the proliferation phase to wound maturation [10,51], which could also be related to the findings regarding the extracellular matrix.…”
Section: Discussion
mentioning
confidence: 69%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…As for the sulfadizine-treated group, previous studies also endorse the above observation, showing that silver sulfadizine not only has antimicrobial properties, but can also modulate the inflammatory response [10], through its interaction with proteins and enzymes within immune cells, especially macrophages, affecting signalling pathways crucial for the transcription of proinflammatory genes, such as TNFα, involving the modulation of transcription factors such as NF-κβ, which plays a central role in regulating TNFα expression [49]. This would explain why the application of sulfadizine to burns reduced the expression of TNFα, leading to more effective healing of these lesions [50].…”
Section: Discussion
supporting
confidence: 54%
“…Pro-inflammatory cellular activity, especially of neutrophils and the release of cytokines, as discussed above, also contribute to the formation of ROS and NROS, which eventually lead to lipoperoxidation, which in turn contributes to greater tissue degeneration at the site of injury, due to the increased concentration of MDAs since cell membranes are rich in polyunsaturated fatty acids, a vulnerable target for ROS [2,38]. Thus, we found that there was a gradual reduction in the concentration of enzymes of the antioxidant system, SOD and CAT and in the evaluation of both enzymes, the most significant reduction in their expression occurred in groups SUL + PBM and SER + PBM, possibly because these groups, due to the combination of treatments, were led to an early maturation of the injured tissue, already transitioning from the proliferation phase to wound maturation [10,51], which could also be related to the findings regarding the extracellular matrix.…”
Section: Discussion
mentioning
confidence: 69%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…One of the main drawbacks of SSD is its potential to impair epithelialization and wound healing due to the silver’s cytotoxic effect on fibroblasts and keratinocytes. This effect has been observed in many clinical studies where SSD was compared to alternative dressings or topical antimicrobials [ 14 , 29 ]. While much of this evidence is low quality, there seems to be a consistent pattern showing that SSD delays healing of superficial burns [ 14 ].…”
Section: Review
mentioning
confidence: 71%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…Ag has long been recognized as an effective treatment for burn wounds, dating back to ancient times and still in use today. [ 49 ] Recently, Ag has been engineered as a nanomaterial due to its enhanced efficacy in biomedical applications and antimicrobial properties. [ 50 ] AgNPs undergo slow oxidation reactions to generate silver ions (Ag+), exhibiting antibacterial activity while avoiding adverse reactions from a sudden local release of high concentrations of Ag + .…”
Section: Results
mentioning
confidence: 99%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…As for the sulfadizine-treated group, previous studies also endorse the above observation, showing that silver sulfadizine not only has antimicrobial properties, but can also modulate the inflammatory response [10], through its interaction with proteins and enzymes within immune cells, especially macrophages, affecting signalling pathways crucial for the transcription of proinflammatory genes, such as TNFα, involving the modulation of transcription factors such as NF-κβ, which plays a central role in regulating TNFα expression [49]. This would explain why the application of sulfadizine to burns reduced the expression of TNFα, leading to more effective healing of these lesions [50].…”
Section: Discussion
supporting
confidence: 54%
“…Pro-inflammatory cellular activity, especially of neutrophils and the release of cytokines, as discussed above, also contribute to the formation of ROS and NROS, which eventually lead to lipoperoxidation, which in turn contributes to greater tissue degeneration at the site of injury, due to the increased concentration of MDAs since cell membranes are rich in polyunsaturated fatty acids, a vulnerable target for ROS [2,38]. Thus, we found that there was a gradual reduction in the concentration of enzymes of the antioxidant system, SOD and CAT and in the evaluation of both enzymes, the most significant reduction in their expression occurred in groups SUL + PBM and SER + PBM, possibly because these groups, due to the combination of treatments, were led to an early maturation of the injured tissue, already transitioning from the proliferation phase to wound maturation [10,51], which could also be related to the findings regarding the extracellular matrix.…”
Section: Discussion
mentioning
confidence: 69%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…One of the main drawbacks of SSD is its potential to impair epithelialization and wound healing due to the silver’s cytotoxic effect on fibroblasts and keratinocytes. This effect has been observed in many clinical studies where SSD was compared to alternative dressings or topical antimicrobials [ 14 , 29 ]. While much of this evidence is low quality, there seems to be a consistent pattern showing that SSD delays healing of superficial burns [ 14 ].…”
Section: Review
mentioning
confidence: 71%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…Ag has long been recognized as an effective treatment for burn wounds, dating back to ancient times and still in use today. [ 49 ] Recently, Ag has been engineered as a nanomaterial due to its enhanced efficacy in biomedical applications and antimicrobial properties. [ 50 ] AgNPs undergo slow oxidation reactions to generate silver ions (Ag+), exhibiting antibacterial activity while avoiding adverse reactions from a sudden local release of high concentrations of Ag + .…”
Section: Results
mentioning
confidence: 99%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…As for the sulfadizine-treated group, previous studies also endorse the above observation, showing that silver sulfadizine not only has antimicrobial properties, but can also modulate the inflammatory response [10], through its interaction with proteins and enzymes within immune cells, especially macrophages, affecting signalling pathways crucial for the transcription of proinflammatory genes, such as TNFα, involving the modulation of transcription factors such as NF-κβ, which plays a central role in regulating TNFα expression [49]. This would explain why the application of sulfadizine to burns reduced the expression of TNFα, leading to more effective healing of these lesions [50].…”
Section: Discussion
supporting
confidence: 54%
“…Pro-inflammatory cellular activity, especially of neutrophils and the release of cytokines, as discussed above, also contribute to the formation of ROS and NROS, which eventually lead to lipoperoxidation, which in turn contributes to greater tissue degeneration at the site of injury, due to the increased concentration of MDAs since cell membranes are rich in polyunsaturated fatty acids, a vulnerable target for ROS [2,38]. Thus, we found that there was a gradual reduction in the concentration of enzymes of the antioxidant system, SOD and CAT and in the evaluation of both enzymes, the most significant reduction in their expression occurred in groups SUL + PBM and SER + PBM, possibly because these groups, due to the combination of treatments, were led to an early maturation of the injured tissue, already transitioning from the proliferation phase to wound maturation [10,51], which could also be related to the findings regarding the extracellular matrix.…”
Section: Discussion
mentioning
confidence: 69%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…One of the main drawbacks of SSD is its potential to impair epithelialization and wound healing due to the silver’s cytotoxic effect on fibroblasts and keratinocytes. This effect has been observed in many clinical studies where SSD was compared to alternative dressings or topical antimicrobials [ 14 , 29 ]. While much of this evidence is low quality, there seems to be a consistent pattern showing that SSD delays healing of superficial burns [ 14 ].…”
Section: Review
mentioning
confidence: 71%
Abstract
Smart CitationsHow this paper cites the one you are viewing
“…Ag has long been recognized as an effective treatment for burn wounds, dating back to ancient times and still in use today. [ 49 ] Recently, Ag has been engineered as a nanomaterial due to its enhanced efficacy in biomedical applications and antimicrobial properties. [ 50 ] AgNPs undergo slow oxidation reactions to generate silver ions (Ag+), exhibiting antibacterial activity while avoiding adverse reactions from a sudden local release of high concentrations of Ag + .…”
Section: Results
mentioning
confidence: 99%
