Macrophage biology in development, homeostasis and disease

“…Rodent studies support a role for ATM in the pro-and anti-inflammatory states as well as insulin resistance in obesity (13,25,48), whereas our findings did not support our hypothesis that abdominal subcutaneous ATM burden is strongly related to insulin resistance and systematic inflammation. It is possible that the degree of obesity explains the contrast between these findings.…”

“…Biological processes enriched among the genes differentially expressed between IDO1-KO and WT in the microglia included ensheathment (envelop) of neurons and the cellular, chemical, and ion homeostasis, and homeostatic process ( Table 7 ). Consistent with our findings, microglia promotes neuronal growth and survival [ 103 ] and maintains homeostasis in the brain [ 104 ]. Proteolipid protein (myelin) 1 (PLP1) and gap junction protein, gamma 3 (GJC3) were affiliated to the categories ensheathment of neurons and were under-expressed in IDO1-KO relative to WT mice.…”

“…According to our results and other studies [51] , [55] , macrophages possess a higher tolerance to ROS than other cells. In this antiviral system, Ag-TiO 2 SAN efficiently eliminated SARS-CoV2 pseudovirus in lysosomes of macrophages.…”

“…Rodent studies support a role for ATM in the pro-and anti-inflammatory states as well as insulin resistance in obesity (13,25,48), whereas our findings did not support our hypothesis that abdominal subcutaneous ATM burden is strongly related to insulin resistance and systematic inflammation. It is possible that the degree of obesity explains the contrast between these findings.…”

“…Biological processes enriched among the genes differentially expressed between IDO1-KO and WT in the microglia included ensheathment (envelop) of neurons and the cellular, chemical, and ion homeostasis, and homeostatic process ( Table 7 ). Consistent with our findings, microglia promotes neuronal growth and survival [ 103 ] and maintains homeostasis in the brain [ 104 ]. Proteolipid protein (myelin) 1 (PLP1) and gap junction protein, gamma 3 (GJC3) were affiliated to the categories ensheathment of neurons and were under-expressed in IDO1-KO relative to WT mice.…”

“…According to our results and other studies [51] , [55] , macrophages possess a higher tolerance to ROS than other cells. In this antiviral system, Ag-TiO 2 SAN efficiently eliminated SARS-CoV2 pseudovirus in lysosomes of macrophages.…”

“…Rodent studies support a role for ATM in the pro-and anti-inflammatory states as well as insulin resistance in obesity (13,25,48), whereas our findings did not support our hypothesis that abdominal subcutaneous ATM burden is strongly related to insulin resistance and systematic inflammation. It is possible that the degree of obesity explains the contrast between these findings.…”

“…Biological processes enriched among the genes differentially expressed between IDO1-KO and WT in the microglia included ensheathment (envelop) of neurons and the cellular, chemical, and ion homeostasis, and homeostatic process ( Table 7 ). Consistent with our findings, microglia promotes neuronal growth and survival [ 103 ] and maintains homeostasis in the brain [ 104 ]. Proteolipid protein (myelin) 1 (PLP1) and gap junction protein, gamma 3 (GJC3) were affiliated to the categories ensheathment of neurons and were under-expressed in IDO1-KO relative to WT mice.…”

“…According to our results and other studies [51] , [55] , macrophages possess a higher tolerance to ROS than other cells. In this antiviral system, Ag-TiO 2 SAN efficiently eliminated SARS-CoV2 pseudovirus in lysosomes of macrophages.…”