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Review
. 2017 Sep;362(3):474-488.
doi: 10.1124/jpet.116.238501. Epub 2017 Jun 19.

Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment

Anna Moszczynska  1 , Sean Patrick Callan  2
Affiliations
Review

Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment

Anna Moszczynska et al. J Pharmacol Exp Ther. 2017 Sep.

Abstract

Understanding the relationship between the molecular mechanisms underlying neurotoxicity of high-dose methamphetamine (METH) and related clinical manifestations is imperative for providing more effective treatments for human METH users. This article provides an overview of clinical manifestations of METH neurotoxicity to the central nervous system and neurobiology underlying the consequences of administration of neurotoxic METH doses, and discusses implications of METH neurotoxicity for treatment of human abusers of the drug.

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