{"id":"https://openalex.org/W1620276316","doi":"https://doi.org/10.1109/tmscs.2015.2478442","title":"Computational Synthetic Biology: Progress and the Road Ahead","display_name":"Computational Synthetic Biology: Progress and the Road Ahead","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1620276316","doi":"https://doi.org/10.1109/tmscs.2015.2478442","mag":"1620276316"},"language":"en","primary_location":{"id":"doi:10.1109/tmscs.2015.2478442","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmscs.2015.2478442","pdf_url":null,"source":{"id":"https://openalex.org/S4210201583","display_name":"IEEE Transactions on Multi-Scale Computing Systems","issn_l":"2332-7766","issn":["2332-7766","2372-207X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Multi-Scale Computing Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111386695","display_name":"Chris J. Myers","orcid":null},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chris J. Myers","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT","Department of Electrical and Computer Engineering, University of Utah, Salt Lake City,UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Utah, Salt Lake City,UT","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111386695"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":0.1478,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.54608846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"1","issue":"1","first_page":"19","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9843000173568726,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.7875540852546692},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.6806390285491943},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.6352124810218811},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.545593798160553},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4309002459049225},{"id":"https://openalex.org/keywords/computational-simulation","display_name":"Computational simulation","score":0.43051019310951233},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.39222633838653564},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.30242204666137695},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2337668240070343},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.224828839302063},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.21118402481079102},{"id":"https://openalex.org/keywords/computational-science","display_name":"Computational science","score":0.15343666076660156}],"concepts":[{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.7875540852546692},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6806390285491943},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.6352124810218811},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.545593798160553},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4309002459049225},{"id":"https://openalex.org/C2987190108","wikidata":"https://www.wikidata.org/wiki/Q925667","display_name":"Computational simulation","level":2,"score":0.43051019310951233},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.39222633838653564},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.30242204666137695},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2337668240070343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.224828839302063},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.21118402481079102},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.15343666076660156}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/tmscs.2015.2478442","is_oa":false,"landing_page_url":"https://doi.org/10.1109/tmscs.2015.2478442","pdf_url":null,"source":{"id":"https://openalex.org/S4210201583","display_name":"IEEE Transactions on Multi-Scale Computing Systems","issn_l":"2332-7766","issn":["2332-7766","2372-207X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319808","host_organization_name":"Institute of Electrical and Electronics Engineers","host_organization_lineage":["https://openalex.org/P4310319808"],"host_organization_lineage_names":["Institute of Electrical and Electronics Engineers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IEEE Transactions on Multi-Scale Computing Systems","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320335357","display_name":"Guangdong Academy of Sciences","ror":"https://ror.org/01g9hkj35"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W11463020","https://openalex.org/W35463602","https://openalex.org/W174102300","https://openalex.org/W246981074","https://openalex.org/W617423901","https://openalex.org/W1499965417","https://openalex.org/W1509581155","https://openalex.org/W1514324734","https://openalex.org/W1516256348","https://openalex.org/W1535517661","https://openalex.org/W1573985420","https://openalex.org/W1609175937","https://openalex.org/W1609903326","https://openalex.org/W1666015432","https://openalex.org/W1842089573","https://openalex.org/W1890385119","https://openalex.org/W1946177469","https://openalex.org/W1967575124","https://openalex.org/W1968856189","https://openalex.org/W1969128394","https://openalex.org/W1969709265","https://openalex.org/W1970221707","https://openalex.org/W1973256834","https://openalex.org/W1973890190","https://openalex.org/W1974272479","https://openalex.org/W1981960889","https://openalex.org/W1987003260","https://openalex.org/W1987602805","https://openalex.org/W1988498168","https://openalex.org/W1996756820","https://openalex.org/W1997982531","https://openalex.org/W2007072455","https://openalex.org/W2011432832","https://openalex.org/W2016554416","https://openalex.org/W2018075920","https://openalex.org/W2018670096","https://openalex.org/W2034375827","https://openalex.org/W2041226400","https://openalex.org/W2041985017","https://openalex.org/W2042880070","https://openalex.org/W2047882868","https://openalex.org/W2060184615","https://openalex.org/W2066594542","https://openalex.org/W2069157810","https://openalex.org/W2074681199","https://openalex.org/W2074743596","https://openalex.org/W2078734278","https://openalex.org/W2079510257","https://openalex.org/W2088846696","https://openalex.org/W2091167328","https://openalex.org/W2094318956","https://openalex.org/W2101506009","https://openalex.org/W2101645257","https://openalex.org/W2105662588","https://openalex.org/W2111870329","https://openalex.org/W2113328169","https://openalex.org/W2114942707","https://openalex.org/W2118464978","https://openalex.org/W2123783513","https://openalex.org/W2134759932","https://openalex.org/W2141881497","https://openalex.org/W2146762168","https://openalex.org/W2147306790","https://openalex.org/W2149202606","https://openalex.org/W2150908245","https://openalex.org/W2151690182","https://openalex.org/W2153517004","https://openalex.org/W2155418451","https://openalex.org/W2158592422","https://openalex.org/W2158979830","https://openalex.org/W2164424555","https://openalex.org/W2169360734","https://openalex.org/W2171582839","https://openalex.org/W2172162088","https://openalex.org/W2193022020","https://openalex.org/W2210452078","https://openalex.org/W2256672332","https://openalex.org/W2312596015","https://openalex.org/W2316537542","https://openalex.org/W2317244104","https://openalex.org/W2317757279","https://openalex.org/W2321143980","https://openalex.org/W2325072505","https://openalex.org/W2330740149","https://openalex.org/W2424114601","https://openalex.org/W2427843410","https://openalex.org/W2622039200","https://openalex.org/W2952317844","https://openalex.org/W4240746805","https://openalex.org/W4246421415","https://openalex.org/W6600468128","https://openalex.org/W6638861505","https://openalex.org/W6692063782","https://openalex.org/W6699417029","https://openalex.org/W6717835706"],"related_works":["https://openalex.org/W33666849","https://openalex.org/W1569631234","https://openalex.org/W3105486044","https://openalex.org/W2059824688","https://openalex.org/W2360038484","https://openalex.org/W2982621060","https://openalex.org/W4230179946","https://openalex.org/W4380301850","https://openalex.org/W4283759179","https://openalex.org/W1555687223"],"abstract_inverted_index":{"Synthetic":[0],"biology":[1],"promises":[2],"to":[3,7,26,52,58],"leverage":[4],"engineering":[5],"principles":[6],"enable":[8],"model-based":[9],"design":[10],"of":[11,82],"genetic":[12],"circuits.":[13],"To":[14],"be":[15,53],"successful,":[16],"advancements":[17],"are":[18],"needed":[19],"in":[20,79],"both":[21],"experimental":[22,63,70],"and":[23,44,69,85],"computational":[24,39,56,68],"methods":[25,57],"support":[27],"this":[28],"new":[29],"approach.":[30],"This":[31],"paper":[32],"focuses":[33],"on":[34,37,62],"the":[35,38,41,45,74,80,86],"progress":[36],"side,":[40],"remaining":[42],"challenges,":[43],"road":[46],"ahead.":[47],"While":[48],"much":[49],"work":[50],"remains":[51],"done":[54],"for":[55,76],"truly":[59],"have":[60,73],"impact":[61,78],"synthetic":[64,71],"biology,":[65],"collaborations":[66],"between":[67],"biologists":[72],"potential":[75],"tremendous":[77],"areas":[81],"health,":[83],"energy,":[84],"environment.":[87]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}